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The ini-tial contact with a specific antigen or foreign agent initi-ates a chain of reactions that involve effector cells of theimmune system and frequently leads to a state of im-mune “memory.” Adaptive immunity induces acquiredresistance against microbial aggression through ran-dom somatic rearrangements of genes that encode im-munoglobulins and specific receptors on T lymphocytes(i.e., T-cell receptors orTCRs). Clinical use of IV antibiotics and antibi-otic-loaded bone cement in arthroplasty grew sporadically throughout the 1970s and wasfollowed only later with detailed characterization in controlled animal models [56].Mainstay surgical techniques in the treatment of established infection such as debride-ment, stabilization, and lavage have also been characterized after the fact, rather thandeveloped with the help of animal models [93]. Perioperative testing for joint infec-tion in patients undergoing revision total hip arthroplasty. Without a trend, the software willnot be able to accurately model the data

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